Published on Feb 29, 2024 | 3:49 PM
Estimated to affect around 1.2 million Americans, the human immunodeficiency virus, or HIV, is a prominent sexually transmitted disease in the United States and globally. (1) Having first been reported in what is now Kinshasa, the capital of the Democratic Republic of the Congo, in 1959, the STD would go on to spread globally, being the subject of great concern in 1981 during the AIDs pandemic in the United States during Ronald Reagan’s presidency. (2)(3) Known to destroy immune cells as it progresses, HIV can result in a number of different symptoms and can remain in the body for the rest of the person’s lifetime before developing into acquired immunodeficiency syndrome (AIDS). While there is no HIV cure, HIV treatment reduces the viral load in the blood, suppresses symptoms, heavily reduces the chance of spread, and forces the infection into dormancy.
When it comes to recognizing whether you have HIV or not, getting tested is the only way to know for sure. (4) In the early stage, the condition can easily be confused with conditions like the flu and other sexually transmitted diseases, making regular STD screening important for anyone considered sexually active.
HIV symptoms are defined in three stages that help to identify its level of progression in the human body. The stages recognized as acute HIV infection, clinical latency, and then acquired immunodeficiency syndrome, the first symptoms tend to arise two to four weeks after the initial sexual exposure as part of the infection’s first stage. (5)
Stage 1: Also known as an acute HIV infection or acute retroviral syndrome (ARS), HIV in the first stage begins replicating at an aggressive rate and targets the immune system, specifically destroying CD4 cells or T cells. (6) Most often lasting a week to a month, the body will try to fight off the sexually transmitted infection, resulting in flu-like symptoms These symptoms can include:
While these symptoms are meant to combat an HIV infection, the natural response should not be considered effective against the condition, and those at this stage should seek out treatment immediately. There has never been an instance where the human body has successfully cleared an HIV infection once it has been successfully transmitted via blood or sex. (12)
Stage 2: In the second stage of HIV infection, known as the chronic or clinical latency stage, the virus continues to replicate at lower levels that don’t warrant an immune system response. It varies heavily on how long it lasts, with many cases lasting up to around a decade, and can last longer or advance to the next stage faster, depending on the patient. The virus can still be spread despite the patient’s lack of symptoms. (6)
Stage 3: In the third stage of HIV infection, known as AIDS (Acquired Immunodeficiency Syndrome), the immune system is severely compromised, leaving the individual vulnerable to opportunistic infections and certain types of cancers. Without treatment, AIDS can lead to life-threatening illnesses and a significant decline in health. The diagnosis of AIDS is typically made based on the presence of specific opportunistic infections or a low CD4 cell count below a certain threshold, indicating advanced immune suppression. (6)
What HIV does to your body starts at the smallest level, as it constantly attacks the immune system and progressively reduces your ability to naturally resist other conditions. Additionally, how HIV affects the body may differ slightly based on gender, with men and women having unique symptoms that can indicate an HIV infection or other sexually transmitted disease. While most of the time, the condition is the same for both genders, it's important to understand the symptoms that it can develop.
HIV in Men: As HIV progresses throughout the body, it can affect a man’s hormones via the testicles, visibly show up as painful sores on the penis, and can make urination and ejaculation uncomfortable. More specifically, these symptoms can arise as:
HIV in Women: Most often in the later stages of an HIV infection, women may experience HIV symptoms that affect the genitals and urinary tract. Possible without treatment, these symptoms can include:
HIV symptoms can appear at different times for different individuals. In general, symptoms of acute HIV infection may appear within 2 to 4 weeks after initial infection, although it can take up to several months for symptoms to manifest in some cases.
Most patients report there being no symptoms in the resulting second stage, which can last several years and severely weaken the body. If HIV treatment is not sought out, the person will develop AIDS and not only become sick far more frequently but have severe difficulty staying healthy.
Of the over one million people suspected of having HIV, it's estimated that 15 percent, or one in seven people, are living without an HIV diagnosis. (17) While it's less common in the first stage for HIV to be asymptomatic, it's still possible. Not only that but the second stage of HIV is known to be asymptomatic as its viral load remains low enough not to trigger an immune system response while still directly affecting the body. It is possible for HIV to be asymptomatic up until a person develops AIDS, where the body will begin to get bombarded by both the initial infection and conditions that it could normally stave off through the immune system.
Yes, HIV symptoms can arise and fade within a month and not recur thereafter. While the symptoms may fade, the infection is still present and can be spread.
HIV symptoms can definitely feel similar to conditions that affect the upper respiratory system, like Covid-19, influenza, and strep throat due to fever, fatigue, muscle aches, and sore throat. Additionally, there are a number of sexually transmitted diseases that may be mistaken for the disease.
Common sexually transmitted diseases like chlamydia and gonorrhea are frequent subjects of confusion for those with HIV symptoms, which is why Call-On-Doc recommends regular double or triple testing when you are sexually active. Additionally, herpes and syphilis are two conditions that can be similar to HIV, due to how they develop in the body and the symptoms produced.
HIV is caused by a retrovirus, specifically the HIV-1 and HIV-2 strains. (2) A retrovirus is a type of RNA virus that replicates by converting its RNA genome into DNA and integrating it into the host cell's genome. This process, called reverse transcription, is carried out by an enzyme called reverse transcriptase, which is unique to retroviruses. Once it infects a person, HIV spreads by a few means, namely:
No, HIV cannot be spread through saliva. The virus is not present in sufficient quantities in saliva to transmit infection.
While there are some tests to detect HIV through urine, the infection cannot be passed on through that bodily fluid. The infection is not able to survive for long outside of the body and is not available in strong enough concentrations in urine or feces to pass onto another subject. (18)
No, HIV cannot be transmitted through sweat. The virus is not present in sweat, and therefore, it is not a mode of transmission for HIV.
Yes, HIV can be transmitted through breast milk. If a mother is HIV-positive, there is a risk of passing the virus to her infant through breastfeeding. However, antiretroviral therapy (ART) can significantly reduce this risk, and in many settings, alternative feeding methods are recommended to prevent mother-to-child transmission of HIV.(19)
The only way to know for sure a person has HIV is through testing, specifically through screening and then confirmatory testing. As detailed in Call-On-Doc Focus: When to get Tested for HIV, the most reliable and common types of tests in each category include:
Screening Tests |
Confirmatory Tests |
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Screening tests for HIV are designed to quickly identify individuals who may be infected with the virus. These tests are often rapid and relatively inexpensive, making them suitable for widespread use. However, screening tests may sometimes produce false-positive results due to factors such as cross-reactivity with other antibodies or antigens, leading to the need for confirmation tests.
Confirmation tests for HIV are more specialized laboratory-based assays that are performed to confirm the presence of HIV infection in individuals who have tested positive on a screening test. These tests are typically more sensitive and specific than screening tests, helping to distinguish true HIV infection from false positives. Confirmation tests directly detect specific HIV antibodies or the genetic material (RNA or DNA) of the virus, providing a definitive diagnosis of HIV infection.
Both screening and confirmation tests are needed in HIV testing protocols to ensure accurate diagnosis and appropriate management of individuals who test positive for HIV. Screening tests help identify individuals who may be infected with HIV, while confirmation tests confirm the diagnosis and rule out false-positive results, ensuring that individuals receive the necessary medical care and support.
A positive screening test for HIV can sometimes be confused with other conditions or factors that may cause false-positive results. For example, certain medical conditions, recent vaccinations, or pregnancy can lead to false-positive results on HIV screening tests. Therefore, confirmation tests are essential to confirm the presence of HIV infection and distinguish true positives from false positives, ensuring accurate diagnosis and appropriate management of individuals who test positive for HIV.
Current HIV tests are highly accurate, with negative results having over a 99.9 percent accuracy rate, though accuracy depends on factors such as the type of test used and the timing of testing in relation to exposure. Initially, HIV infection is difficult to detect during the acute stage, but it becomes easier to diagnose over time as it progresses to the chronic stage.
Yes, HIV has a window period, which refers to the time between when a person is first infected with HIV and when HIV tests can reliably detect the virus. During this period, individuals may test negative for HIV even though they are infected, as their immune system has not yet produced enough antibodies or antigens for detection. The length of the window period varies depending on the type of test used, but it can range from a few weeks to a few months. It's essential to consider the window period when interpreting HIV test results, especially if testing is soon after potential exposure.
No, HIV does not go away on its own nor by the body’s natural means. HIV is a chronic viral infection that persists for life if left untreated. However, with proper medical care and adherence to HIV treatment, people living with HIV can effectively manage the virus and lead long, healthy lives.
Yes, HIV can be treated effectively with antiretroviral therapy (ART), which helps suppress the replication of the virus in the body, allowing individuals to live long, healthy lives. Additionally, there are preventive measures Call-On-Doc offers to reduce the risk of HIV transmission:
Pre-exposure prophylaxis (PrEP): PrEP involves taking a daily medication regimen of antiretroviral drugs by HIV-negative individuals who are at high risk of HIV infection, such as those with an HIV-positive partner or individuals engaging in high-risk behaviors like unprotected sex or injection drug use. When taken consistently as prescribed, PrEP can significantly reduce the risk of acquiring HIV.
Post-exposure prophylaxis (PEP): PEP is an emergency measure taken within 72 hours of potential exposure to HIV, such as unprotected sex or needle-sharing with an HIV-positive individual. It involves taking a 28-day course of antiretroviral drugs to prevent HIV infection. PEP should be initiated as soon as possible after exposure for maximum effectiveness.
HIV PrEP (Pre-exposure prophylaxis) and HIV PEP (Post-exposure prophylaxis) are both preventive strategies used to reduce the risk of HIV transmission, but they differ in timing and usage.
HIV PrEP |
HIV PEP |
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PrEP involves taking a daily medication regimen of antiretroviral drugs by HIV-negative individuals who are at high risk of HIV infection, such as those with an HIV-positive partner or individuals engaging in high-risk behaviors like unprotected sex or injection drug use. When taken consistently as prescribed, PrEP can significantly reduce the risk of acquiring HIV.
PEP is an emergency measure taken within 72 hours of potential exposure to HIV, such as unprotected sex or needle-sharing with an HIV-positive individual. It involves taking a 28-day course of antiretroviral drugs to prevent HIV infection. PEP should be initiated as soon as possible after exposure for maximum effectiveness.
While there is no cure, there are practices that help a person stay as healthy as possible alongside HIV treatment. When undergoing antiretroviral therapy, individuals living with HIV lead long, healthy lives and are able to gain a sense of normalcy. Healthy lifestyle choices and habits additionally make HIV treatment more effective.
There are a number of habits and changes a patient can commit to so that HIV does not rule their life and develop into AIDs. These can include:
Over the last decades, HIV and AIDS have been reduced to a condition that we as a society can manage. While not an easy endeavor, the following steps will help you understand how:
When it comes to having the best chance of avoiding an HIV infection, HIV PEP and HIV PrEP prove to be some of the best options available. Call-On-Doc makes both available to anyone needing either treatment while also offering 50% off partner treatment so you can help manage the spread. The entire process is easy, private, and designed to bring you peace of mind!
English graduate and Call-On-Doc’s medical resource guide, Wayne C. Hahne is an experienced and passionate medical education content expert. Through diligent research, provider interviews and utilizing the industry's leading resources for wellness information, it is Mr. Hahne’s personal mission to educate the general public on medical conditions with in-depth and easy-to-understand written guides.
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