Malaria is an important cause of fever and serious illness in returned travelers. In general, most chemoprophylaxis regimens are designed to prevent primary attacks of malaria.
1. Atovaquone-proguanil: may include gastrointestinal upset, insomnia, headache, rash, and mouth ulcers
2. Chloroquine: bitter taste, with minor gastrointestinal disturbances, dizziness, blurred vision, and headache
3. Primaquine can cause hemolytic anemia in those with G6PD deficiency. Primaquine may also cause gastrointestinal upset that can be minimized if taken with food.